Sheryl Leventhal, MD

Founder of Hudson Valley Longevity Medicine

After spending 13 years practicing Hematology Oncology, in 2005 I switched my focus to Functional Medicine, a newer systems approach to medicine. I was in the third graduating class of fellows that studied and certified through The Institute for Functional Medicine, which is now going on its 30th year. As someone hungry to learn and improve care, in the last six years, I have followed the proliferation of medical studies, articles, books, podcasts, and websites in the emerging field of Longevity. With the celebration of my 60th birthday coupled with my determination to remain vibrant and fit, I embarked upon a deep study of the new genomics and physiology of aging, and am now I am eager to share what I’m learning with patients by offering integrated, comprehensive Longevity Medicine focused on genomics, fitness, and immunity, that can help each patient hedge against future disease and realize their full potential to live healthfully throughout the remainder of their lives.

My passion for health sciences and obsession with remaining on the leading edge of medicine started with my first introduction to biology working at the National Institutes of Health during high school and summers. At Cornell University I fell in love with biochemistry and was able to take courses in nutrition, research science, and work in the lab. At NYU medical school I was drawn in even further, as the curriculum of cell biology, a new discipline at the time, was very strong. I graduated from NYU Medical School with honors in Pharmacology, which required a research project and presentation. After having the opportunity to work at the Weizmann Institute of Science in Israel in an immunology lab, I decided to focus on Oncology and Hematology. I was taken by the close connection of Oncology with biochemistry and physiology, and the challenge of moving treatments forward in a field where outcomes were not always favorable. After my fellowships in Hematology and Oncology, I took an opportunity at Columbia University, to teach as an adjunct clinical professor, and participate in nationwide clinical trials, while running a community practice with four partners. This 13-year experience was rewarding and certainly, there were some small advancements in my field, but I remained intensely curious about the root causes of cancer, and why prevention was not prioritized. I felt often that I was working at the wrong end of the continuum. At the time I did not know that there was a burgeoning group of like-minded professionals beginning to organize around concepts of root-cause exploration, the role of the environment in disease, and the healing power of food.

In 2005 I stumbled upon Functional Medicine and my world was turned upside down. Functional Medicine seemed to combine everything I love, nutritional biochemistry, natural health emphasis, and treating patients for foundational imbalances. I felt compelled to leave my Hematology Oncology practice and retrain in Functional Medicine at the Institute of Functional Medicine. Now, with the availability of genomic analysis and the new research in Longevity, I feel the science of Longevity, combined with the fundamentals of Functional Medicine, provides a very sound prescription for aging healthfully, with minimal medical intervention.

With so many potential approaches to Longevity, and so much science coming out every day, we decided to focus on three things: fitness and body composition, genomic variations and how they drive various metabolic pathways, and how the immune system ages. Once again, I had to re-train, taking courses on genomics, getting certified in exercise testing and prescription, and studying the newest tests to define an “immune age” vs “chronological age”. I have organized our Longevity practice into these three tracks because I feel these are the most foundational areas that should be measured and addressed first.

It is very exciting to be able to combine my background in Functional Medicine, to help others remain in optimal health for as long as possible.


Kane PC, Cartaxo AL, Pouria S, Leventhal SL, Downing D, Holsworth RE
McLaren-Howard J, Bieber K, Milz M, Gedroic KL.  Stabilizing Membranes in Lipid Storage Disorders by addressing Epigenetics with Phospholipids.  National Organization for Rare Disorders (NORD) Rare Diseases Breakthrough Summit, Oct 21-22, 2014, Washington, DC

TAYLOR, S.I., MARCUS-SAMUELS, B.E.R.N.I.C.E., RYAN-YOUNG, J.A.N.I.C.E., LEVENTHAL, S. and ELDERS, M.J., 1986. Genetics of the insulin receptor defect in a patient with extreme insulin resistance. The Journal of Clinical Endocrinology & Metabolism, 62(6), pp.1130-1135. Link to article>>

Taylor, S.I. and Leventhal, S.H.E.R.Y.L., 1983. Defect in cooperativity in insulin receptors from a patient with a congenital form of extreme insulin resistance. The Journal of clinical investigation, 71(6), pp.1676-1685. Link to article>>


Neurolipid Reseach